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Fmoc-O-tert-Butyl-L-serine


  • CAS
  • Purity
  • 71989-33-8
  • 99%
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What is the Fmoc-O-tert-Butyl-L-serine ?

Fmoc-O-tert-Butyl-L-serine is white to light yellow crystal powder, while it's Molecular Formula is C22H25NO5. Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. Some of the reported examples are:Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.

What is the CAS number for Fmoc-O-tert-Butyl-L-serine ?

The CAS number of Fmoc-O-tert-Butyl-L-serine is 71989-33-8.

More information of Fmoc-O-tert-Butyl-L-serine 71989-33-8 are:

Synonyms

L-Serine,O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;(2S)-3-tert-Butoxy-2-[[[(9H-fluoren-9-yl)methoxy]carbonyl]amino]propanoicacid;N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine;O-tert-Butyl-N-(9-fluorenylmethoxycarbonyl)serine;Fmoc-Ser(tBu)-OH;

CAS?Number

71989-33-8

Molecular Formula

C22H25NO5

Molecular Weight

383.444

Density

1.216 g/cm3

Melting Point

127-131 °C

Boiling Point

578.6 °C at 760 mmHg

Flash Point

303.7 °C

HS CODE

29242990

PSA

84.86000

LogP

4.18430

Pka

3.44±0.10(Predicted)

What is Fmoc-O-tert-Butyl-L-serine (71989-33-8) used for?

Fmoc-O-tert-Butyl-L-serine, also known as Fmoc-Ser(tBu)-OH, is a chemical compound that serves as an N-terminal protected reagent in peptide synthesis. It is a derivative of L-serine, an essential amino acid, with a fluorenylmethoxycarbonyl (Fmoc) group attached to the amino group and a tert-butyl (tBu) protecting group on the hydroxyl group. This structure allows for the controlled synthesis of peptides with specific sequences and properties.

InChI:InChI=1/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/p-1/t19-/m0/s1

Articles related to Fmoc-O-tert-Butyl-L-serine:

Article

Source

Method for preparing Fmoc-Ser (tBu)-OH

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Paragraph 0056; 0060; 0066; 0070-0071; 0075-0076; 0080-0081, (2020/12/30)

MgI2-Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies

Berthet, Mathéo,Davanier, Florian,Dujardin, Gilles,Martinez, Jean,Parrot, Isabelle

supporting information, p. 11014 - 11016 (2015/11/10)

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