- CAS
- Purity
- 108-26-9
- 99%
Location：Home > Pharmaceutical
Factory Sells Best Quality 3-Methyl-2-pyrazolin-5-one 108-26-9 with GMP standards
- Molecular Formula: C4H6 N2 O
- Molecular Weight: 98.1044
- Appearance/Colour: pale white crystal powder
- Vapor Pressure: 0.000345mmHg at 25°C
- Melting Point: 220-224 ºC
- Refractive Index: 1.4327 (estimate)
- Boiling Point: 309.7oC at 760 mmHg
- PKA: 13.10±0.40(Predicted)
- Flash Point: 141.1oC
- PSA： 41.46000
- Density: 1.33 g/cm3
- LogP: -0.35340
3-Methyl-2-pyrazolin-5-one(Cas 108-26-9) Usage
InChI:InChI=1/C4H6N2O/c1-3-2-4(7)6-5-3/h2H,1H3,(H2,5,6,7)
108-26-9 Relevant articles
Stereoselective synthesis of trans-3-functionalized-4-pyrazolo[5,1-b]thiazole-3-carboxylate substituted β-lactams: Potential synthons for diverse biologically active agents
Berry, Shiwani,Bari, Shamsher S.,Yadav, Pooja,Garg, Ankita,Khullar, Sadhika,Mandal, Sanjay K.,Bhalla, Aman
, p. 1 - 12 (2020)
An efficient protocol for the stereosele...
Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors
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The design and synthesis of novel pyrazo...
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, p. 113 - 118 (2020)
Pyrazole derivatives were synthesized by...
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, p. 1167 - 1172 (2016)
Uncontrolled metabolism of l-tryptophan ...
SBA-Pr-SO3H-catalyzed synthesis of bispyrazole compounds as anti-bacterial agents and inhibitors of phosphorylated RET tyrosine kinase
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, p. 1401 - 1409 (2019)
Pyrazolone was prepared through the reac...
Synthesis of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5- carbonitriles by heterogeneous reusable catalysts
Shaterian, Hamid Reza,Kangani, Mehrnoosh
, p. 1997 - 2005 (2014)
A new, efficient and environmentally ben...
A new, convenient and expeditious synthesis of 4-alkyl-5-methyl-1H-pyrazol-3-ols in water through a multicomponent reaction
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, p. 566 - 569 (2017)
A new, simple and efficient synthesis of...
Polyethylene glycol-promoted synthesis of pyrimido[1,2-a]benzimidazole and pyrano[2,3-c]pyrazole derivatives in water
Survase, Dattatray,Bandgar, Babasaheb,Helavi, Vasant
, p. 680 - 687 (2017)
Synthesis of pyrimido[1,2-a]benzimidazol...
Heterocyclic derivatives of sugars: The formation of 1-glycosyl-3-methylpyrazol-5-ones from hydrazones
Kett, Warren C,Batley, Michael,Redmond, John W
, p. 169 - 177 (2000)
Conditions to effect the conversion of m...
Synthesis of Pyranopyrazoles Using Magnetically Recyclable Heterogeneous Iron Oxide-silica Core-shell Nanocatalyst
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An efficient, three-component, one-pot s...
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Wang, Zhongwen,Ren, Jun,Li, Zhengming
, p. 763 - 769 (2000)
By a new tandem reaction, in which ethyl...
-
Aggarwal,Ray
, p. 492 (1930)
-
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El-Shwiniy, Walaa H.,Shehab, Wesam S.,Mohamed, Soha F.,Ibrahium, Hend G.
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Pyrazole and their derivatives are found...
Concentrated solar radiation-assisted one-pot/multicomponent synthesis of pyranopyrazole derivatives under neat condition
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Concentrated solar radiation (CSR)-assis...
Facile, one-pot, four-component synthesis of a new series of imidazo[1,2-a]pyridines in presence of TPAB in EtOH under reflux conditions
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Abstract: A convenient, regioselective, ...
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, p. 1190 - 1198 (2018)
A simple, facile, and high yielding ster...
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, (2020)
-
Ein einfacher Weg zu 2-Butynsaeure (Tetrolsaeure)
Simmross, Frank-Michael,Weyerstahl, Peter
, p. 72 (1981)
-
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies
Soares De Melo, Candice,Singh, Vinayak,Myrick, Alissa,Simelane, Sandile B.,Taylor, Dale,Brunschwig, Christel,Lawrence, Nina,Schnappinger, Dirk,Engelhart, Curtis A.,Kumar, Anuradha,Parish, Tanya,Su, Qin,Myers, Timothy G.,Boshoff, Helena I. M.,Barry, Clifton E.,Sirgel, Frederick A.,Van Helden, Paul D.,Buchanan, Kirsteen I.,Bayliss, Tracy,Green, Simon R.,Ray, Peter C.,Wyatt, Paul G.,Basarab, Gregory S.,Eyermann, Charles J.,Chibale, Kelly,Ghorpade, Sandeep R.
supporting information, p. 719 - 740 (2021/02/03)
Phenotypic screening of a Medicines for ...
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Moradi, Leila,Toorbaf, Mahla
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Efficient and green one pot multi compon...
108-26-9 Process route
-
-
54-85-3,7640-37-1
isoniazid
-
-
4329-75-3
N,N'-bis(isonicotinoyl)hydrazine
-
-
100-65-2
N-Phenylhydroxylamine
-
-
143997-57-3
N-hydroxy-N-phenylisonicotinamide
-
-
108-26-9
3-methyl-2-pyrazoline-5-one
Conditions
| Conditions | Yield |
|---|---|
|
With
N,O-diacetylphenylhydroxylamine;
triethylamine;
In
chloroform;
for 24h;
Further byproducts given;
Heating;
|
23%
90% 32.7% 39.5% |
-
-
27991-08-8
N-acetoacetylphenylhydroxyloamine
-
-
4329-75-3
N,N'-bis(isonicotinoyl)hydrazine
-
-
100-65-2
N-Phenylhydroxylamine
-
-
108-26-9
3-methyl-2-pyrazoline-5-one
-
-
495-48-7,55599-32-1
azoxybenzene
Conditions
| Conditions | Yield |
|---|---|
|
With
isoniazid; triethylamine;
In
chloroform;
for 24h;
Further byproducts given;
Heating;
|
32.7%
39.5% 22% 90% |
108-26-9 Upstream products
-
89179-80-6
3-methyl-5-oxo-3-pyrazolin-1-carboxamide
-
5204-15-9
ethyl 3-(acetyl hydrazono)butanoate
-
5982-65-0
N-carboxiamino-hidrazona del acetilacetato de etilo
-
27991-08-8
N-acetoacetylphenylhydroxyloamine
108-26-9 Downstream products
-
68761-49-9
4-benzylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-one
-
7626-82-6
2-benzyl-5-methyl-1,2-dihydro-pyrazol-3-one
-
81905-05-7
4-anilinomethylene-5-methyl-2,4-dihydro-pyrazol-3-one
-
70373-85-2
5-benzo[1,3]dioxol-5-yl-7-(3,4-dichloro-phenyl)-4-methyl-2,4a,5,6-tetrahydro-benzo[f ]indazol-3-one