- CAS
- Purity
- 100-82-3
- 99%
Location：Home > Pharmaceutical
Factory supply 3-Fluorobenzylamine 100-82-3 with sufficient stock and high standard
- Molecular Formula:C7H8FN
- Molecular Weight:125.146
- Appearance/Colour:clear colorless liquid
- Vapor Pressure:1.13mmHg at 25°C
- Melting Point:247-248 °C(Solv: N,N-dimethylformamide (68-12-2))
- Refractive Index:n20/D 1.514(lit.)
- Boiling Point:175.8 °C at 760 mmHg
- PKA:8.80±0.10(Predicted)
- Flash Point:71.1 °C
- PSA：26.02000
- Density:1.097 g/cm3
- LogP:1.98470
3-Fluorobenzylamine(Cas 100-82-3) Usage
InChI:InChI=1/C7H8FN/c8-7-3-1-2-6(4-7)5-9/h1-4H,5,9H2/p+1
100-82-3 Relevant articles
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
Shan, Hengyue,Liu, Jianping,Shen, Jiali,Dai, Jialin,Xu, Gang,Lu, Kuankuan,Han, Chao,Wang, Yaru,Xu, Xiaolong,Tong, Yilun,Xiang, Huaijiang,Ai, Zhiyuan,Zhuang, Guanglei,Hu, Junhao,Zhang, Zheng,Li, Ying,Pan, Lifeng,Tan, Li
, p. 855 - 9,865 (2021/05/18)
The COVID-19 pandemic has been disastrou...
Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity
Tseliou, Vasilis,Schilder, Don,Masman, Marcelo F.,Knaus, Tanja,Mutti, Francesco G.
supporting information, p. 3315 - 3325 (2020/12/11)
The l-lysine-?-dehydrogenase (LysEDH) fr...
Benzimidazole fragment containing Mn-complex catalyzed hydrosilylation of ketones and nitriles
Ganguli, Kasturi,Mandal, Adarsha,Sarkar, Bidisha,Kundu, Sabuj
, (2020/08/13)
The synthesis of a new bidentate (NN)–Mn...
Mild palladium-catalysed highly efficient hydrogenation of CN, C-NO2, and CO bonds using H2 of 1 atm in H2O
Liu, Yaxu,He, Shaopo,Quan, Ziyi,Cai, Huizhuo,Zhao, Yang,Wang, Bo
supporting information, p. 830 - 838 (2019/02/27)
Here we present the first example of a m...
100-82-3 Process route
-
-
456-48-4
3-Fluorobenzaldehyde
-
-
100-82-3
(3-fluorophenyl)methanamine
-
-
456-47-3
3-fluoro-benzenemethanol
Conditions
| Conditions | Yield |
|---|---|
|
With
ammonium hydroxide; ammonium acetate; hydrogen;
[Ru(cod)Cl]2; trisodium tris(3-sulfophenyl)phosphine;
In
tetrahydrofuran;
at 135 ℃;
for 2h;
under 48754.9 Torr;
|
62 % Chromat. 11 % Chromat. |
-
-
403-54-3
m-Fluorobenzonitrile
-
-
100-82-3
(3-fluorophenyl)methanamine
Conditions
| Conditions | Yield |
|---|---|
|
With
borane-ammonia complex; C15H30Cl2CoN3P;
In
hexane;
at 50 ℃;
for 16h;
chemoselective reaction;
Sealed tube;
Inert atmosphere;
|
95% |
|
With
hydrogen;
silica gel; nickel;
In
methanol; ammonia;
at 120 ℃;
for 6h;
under 7600 Torr;
|
86% |
|
With
methanol; sodium tetrahydroborate;
at 20 ℃;
for 3h;
Catalytic behavior;
|
81% |
|
With
[RuH(tBu-PNP(-))(CO)]; hydrogen;
In
benzene;
at 110 ℃;
for 60h;
under 3750.38 Torr;
|
79% |
|
With
diborane;
In
tetrahydrofuran;
|
|
|
With
C26H41Br2FeNP2; hydrogen; potassium hexamethylsilazane; sodium triethylborohydride;
In
tetrahydrofuran;
at 140 ℃;
for 48h;
under 45004.5 Torr;
High pressure;
Autoclave;
|
97 %Chromat. |
|
With
ammonia; hydrogen;
In
methanol;
at 20 ℃;
for 12h;
|
|
|
With
hydrogen;
In
water;
at 20 ℃;
for 8h;
under 760.051 Torr;
pH=1;
chemoselective reaction;
Catalytic behavior;
Green chemistry;
|
99 %Chromat. |
|
With
hydrogen;
In
ethanol;
at 30 ℃;
for 2h;
under 760.051 Torr;
|
|
|
Multi-step reaction with 2 steps
1: C16H11BrMnN3O3 / tetrahydrofuran / 24 h / 120 °C / Inert atmosphere; Sealed tube
2: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
With
water; C16H11BrMnN3O3; sodium hydroxide;
In
tetrahydrofuran; methanol;
|
|
|
With
ammonia; hydrogen;
In
methanol;
at 20 ℃;
for 16h;
|
100-82-3 Upstream products
-
403-54-3
m-Fluorobenzonitrile
-
456-42-8
m-fluorobenzyl chloride
-
456-48-4
3-Fluorobenzaldehyde
-
100-46-9
benzylamine
100-82-3 Downstream products
-
61290-73-1
3-(3-Fluoro-benzyl)-1-(2-hydroxy-ethyl)-1-methyl-thiourea
-
63351-94-0
1-fluoro-3-(isothiocyanatomethyl)benzene
-
112088-66-1
5-amino-4-chloro-6-<(3-fluorobenzyl)amino>pyrimidine
-
123395-24-4
1-(m-fluorophenyl)-4,4-dimethyl-6,6-diphenyl-2-azahexa-1,4-diene