- CAS
- Purity
- 700-37-8
- 99%
Location：Home > Organic Chemicals
Manufacturer supply high quality 4-Chloro-2-fluoronitrobenzene 700-37-8 with ISO standards
- Molecular Formula: C6H3ClFNO2
- Molecular Weight: 175.547
- Appearance/Colour: light brown solid
- Melting Point: 48°C
- Boiling Point: 241.8 °C at 760 mmHg
- Flash Point: 100 °C
- PSA： 45.82000
- Density: 1.494 g/cm3
- LogP: 2.91050
4-Chloro-2-fluoronitrobenzene(Cas 700-37-8) Usage
InChI:InChI=1/C8H8BrFO/c1-11-8-3-2-7(10)4-6(8)5-9/h2-4H,5H2,1H3
700-37-8 Relevant articles
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro- N 2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N 4-(2-(isopropylsulfonyl) phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials
Marsilje, Thomas H.,Pei, Wei,Chen, Bei,Lu, Wenshuo,Uno, Tetsuo,Jin, Yunho,Jiang, Tao,Kim, Sungjoon,Li, Nanxin,Warmuth, Markus,Sarkisova, Yelena,Sun, Frank,Steffy, Auzon,Pferdekamper, Annemarie C.,Li, Allen G.,Joseph, Sean B.,Kim, Young,Liu, Bo,Tuntland, Tove,Cui, Xiaoming,Gray, Nathanael S.,Steensma, Ruo,Wan, Yongqin,Jiang, Jiqing,Chopiuk, Greg,Li, Jie,Gordon, W. Perry,Richmond, Wendy,Johnson, Kevin,Chang, Jonathan,Groessl, Todd,He, You-Qun,Phimister, Andrew,Aycinena, Alex,Lee, Christian C.,Bursulaya, Badry,Karanewsky, Donald S.,Seidel, H. Martin,Harris, Jennifer L.,Michellys, Pierre-Yves
, p. 5675 - 5690 (2013/08/23)
The synthesis, preclinical profile, and ...
Use of nitriles as polar aprotic solvents
-
Page 5, (2008/06/13)
The invention concerns the use of alipha...
Tetramethylammonium chloride as a selective and robust phase transfer catalyst in a solid-liquid halex reaction: The role of water
Sasson, Yoel,Negussie, Samuel,Royz, Michael,Mushkin, Noam
, p. 297 - 298 (2007/10/03)
Tetramethylammonium chloride (TMAC) is a...
Methylhexamethylenetetramine fluoride dihydrate: A new fluorodenitration reagent
Clark, James H.,Nightingale, David J.
, p. 91 - 93 (2007/10/03)
Methylhexamethylenetetramine fluoride di...
700-37-8 Process route
-
-
611-06-3
2,4-dichloronitrobenzene
-
-
2106-50-5
2-chloro-4-fluoro-1-nitrobenzene
-
-
446-35-5
2,4-Difluoronitrobenzene
-
-
700-37-8
4-chloro-2-fluoro-nitrobenzene
Conditions
| Conditions | Yield |
|---|---|
|
With
potassium fluoride; water; tetramethlyammonium chloride;
In
acetic acid;
at 120 ℃;
for 3.5h;
|
70%
|
-
-
611-06-3
2,4-dichloronitrobenzene
-
-
446-35-5
2,4-Difluoronitrobenzene
-
-
700-37-8
4-chloro-2-fluoro-nitrobenzene
Conditions
| Conditions | Yield |
|---|---|
|
With
potassium fluoride; tetramethlyammonium chloride;
In
sulfolane;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
13 %Chromat.
57 %Chromat. |
|
With
cesium fluoride;
In
hexanedinitrile;
at 180 - 220 ℃;
for 0.166667h;
Microwave irradiation;
|
32 - 50 %Chromat.
8 - 54 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
pimelonitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
20 %Chromat.
48 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
octanedinitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
15 %Chromat.
46 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
Glutaronitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
17 %Chromat.
43 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
benzonitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
46 %Chromat.
23 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
hexanedinitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
13 %Chromat.
52 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
2-methylglutaronitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
17 %Chromat.
58 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
phthalonitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
32 %Chromat.
8 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
caprylnitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
44 %Chromat.
26 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
butanedinitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
7 %Chromat.
1 %Chromat. |
|
With
potassium fluoride; tetramethlyammonium chloride;
In
heptanenitrile;
at 170 ℃;
for 4h;
Product distribution / selectivity;
|
30 %Chromat.
5 %Chromat. |
700-37-8 Upstream products
-
611-06-3
2,4-dichloronitrobenzene
-
610-40-2
3,4-dinitro-chlorobenzene
-
625-98-9
3-chlorofluorobenzene
700-37-8 Downstream products
-
925211-88-7
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-
1026490-44-7
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-
28096-58-4
N-cyclohexyl-2-nitro-5-chloro-aniline
-
5010-24-2
N-(5-Chloro-2-nitrophenyl)-N',N'-dimethylethylenediamine